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a16z LiveAuthor: Andreessen Horowitz
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How Startups are Fixing Healthcare Friction
Episode 146
Wednesday, 25 June, 2025
What if the biggest lever for improving U.S. healthcare isn’t clinical, but operational?In this episode, recorded live at New York Tech Week, a16z General Partner David Haber speaks with Trey Holterman (Tennr) and Christophe Rimann (Camber), two founders tackling the core infrastructure problems slowing healthcare down - from broken referral handoffs to denied insurance claims.They discuss building trust in high-stakes workflows, how better incentives (not just better tech) drive adoption, and why the most defensible products aren’t just smart - they work 97%+ of the time.Plus: advice for founders, the cultural edge of New York startups, and what they’d fix first if they ran HHS.Timecodes:00:00 Introduction to Healthcare Payment Innovation00:48 Meet the Founders: Trey Holman and Christophe Reman02:31 The Broken Healthcare System: Identifying the Problems03:47 The Why Now: Technological and Market Shifts05:29 Understanding the Customers and Their Needs06:34 Challenges and Misconceptions in Healthcare Technology08:31 Building a Company in New York City10:29 Leveraging AI and Technology for Better Outcomes12:29 Defensibility and Differentiation in Healthcare Solutions15:28 Impact on Providers and Patients18:09 Advice for Aspiring Healthcare Entrepreneurs23:17 Conclusion and Final ThoughtsResources:Find David on X: https://x.com/dhaberFind Trey on LinkedIn: https://www.linkedin.com/in/trey-holtermanFind Christophe on X: https://www.linkedin.com/in/christopherimann/
