Careers in Discovery

Author: Tom Froggatt

Careers in Discovery is your window into the world of Pharma & Biotech. Featuring interviews each week with leaders in Drug Discovery and R&D, youll learn about the careers of these influential figures, the work they are doing, how they got to where they are and what advice theyd give their younger selves. Brought to you by Singular: Building Brilliant Biotechs. Connect with us at: LinkedIn: https://www.linkedin.com/company/singular-biotech/ www.singular-biotech.com
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Genres: Business

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Marc Damelin, Alphina Therapeutics
Episode 205
Tuesday, 17 February, 2026

In this episode of Careers in Discovery, Tyler is joined by Marc Damelin, Chief Scientific Officer at Alphina Therapeutics. Marc shares his journey from physics undergraduate to Biotech leader, and how a love of problem‑solving gradually drew him from yeast genetics into human disease and ultimately into drug development. After a decade in big pharma working on antibody–drug conjugates, he steps into Biotech leadership, first at Mersana and now at Alphina, where he’s pioneering a new class of ADCs built around NAMPT inhibition. Along the way, Marc reflects on choosing industry without having a clear plan, understanding what makes a role the right fit, and why being truly data‑driven is one of the most important habits a scientist can develop. An open, forward‑looking conversation about evidence, judgment and the momentum that comes from backing the right ideas at the right time.