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Baby or Bust with Dr Lora ShahineAuthor: Dr. Lora Shahine
Fertility, reproductive health, and wellness are deeply personaland sometimes, deeply challenging. Brave & Curious is a space for open, honest conversations about the science, emotions, and decisions that shape our reproductive journeys. Hosted by Dr. Lora Shahine, a double board certified OBGYN and reproductive endocrinologist, author, and advocate, this podcast blends evidence-based medicine with empathy and curiosity. Whether you're navigating infertility, exploring reproductive health, or simply seeking knowledge, this show will equip you with insights, expert interviews, and real stories to support your journey. New episodes drop weeklysubscribe and join the conversation. Until next time, stay brave and curious. Language: en-us Genres: Health & Fitness, Medicine Contact email: Get it Feed URL: Get it iTunes ID: Get it |
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Ep 167 Endometriosis Diagnosis Without Surgery? Dr. Bruce Lessey
Episode 167
Tuesday, 24 March, 2026
Are you struggling with unexplained infertility and wondering if endometriosis could be the missing piece? Have you been told that surgery is the only way to get a diagnosis? What if a simple test could offer answers without going into the operating room? In this episode of Brave & Curious, Dr. Lora Shahine welcomes guest Dr. Bruce Lessey, a double board certified OBGYN and Reproductive Endocrinologist with decades of research experience and over 150 peer-reviewed publications. Together they explore a groundbreaking question in reproductive medicine: can we diagnose endometriosis without invasive surgery? Dr. Lessey and Dr. Shahine explain the science behind BCL6 testing, a biomarker found in the uterine lining that may signal inflammation linked to endometriosis. Dr. Lessey also shares how this research evolved from studying implantation markers to developing a potential non-invasive diagnostic tool, and why timing in the menstrual cycle is critical for accurate results. They also discuss the realities of delayed diagnosis, the connection between endometriosis and unexplained infertility, and how this test is already being used in clinical settings. In this episode you'll hear: [1:21] Meet Dr. Bruce Lessey [4:27] Why does diagnosing endometriosis take years? [7:16] Introducing BCL6 testing [16:20] Timing the biopsy window [22:51] IVF outcomes study [25:42] Fresh vs. frozen transfers [27:22] Treating expected endometriosis [28:44] Lupron and surgery explained [30:42] BCL6 in recurrent pregnancy loss and recurrent implantation failure [33:04] Progesterone resistance and benefits of letrozole [40:48] Timing and testing pitfalls [43:02] Future research and wrap up Resources mentioned: Overexpression in Eutopic Endometrium of Women With Endometriosis. doi: 10.1177/1933719116649711. Endometrial BCL6 testing for the prediction of in vitro fertilization outcomes: a cohort study. doi: 10.1016/j.fertnstert.2017.09.017. Unexplained recurrent pregnancy loss and unexplained infertility: twins in disguise. doi: 10.1093/hropen/hoz021. This episode is sponsored by Cicero Diagnostics. Dr. Shahine's Weekly Newsletter on Fertility News and Recommendations Follow @drlorashahine Instagram | YouTube | Tiktok | Her Books Join the Learn at Pinnacle app to earn FREE CE Credit for listening to this episode! This episode was produced by Audiotocracy Podcast Production.
