Spotlight on Migraine®

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Triptans, DHE, and Ergotamine: Revisiting the Original Acute Migraine Treatments
Episode 8
Thursday, 24 September, 2026

In this episode of Spotlight on Migraine, host Molly O'Brien talks with neurologist and headache medicine specialist Dr. Barbara Nye about the original acute migraine treatments: ergotamine, dihydroergotamine (DHE), and triptans (such as sumatriptan, rizatriptan, etc.). Dr. Nye shares the history and evolution of these treatments, including the formulations, delivery methods, how they work to break an attack, and who may benefit from adding them to their migraine toolbox. Follow Dr. Nye: Instagram Facebook X Bluesky In this video: How ergotamines (such as DHE) and Triptans (such as sumatriptan and rizatriptan) work Why treatment formulation matters Which treatments may help in treating prolonged attacks Why one ineffective triptan doesn't mean others won't work either The safety profiles and side effects of these treatments Dr. Barbara Nye is a paid consultant for a sponsor of the Association of Migraine Disorders. Read the full transcript: https://www.migrainedisorders.org/podcast/revisiting-acute-treatments/ Learn About Preventive Options: Migraine Prevention Explained: When to Start, Why It Matters & What Success Looks Like(opens in new tab) Breaking Down Your Migraine Preventive Options: Medications, Vitamins & Devices *The contents of this podcast are intended for general informational purposes only and do not constitute professional medical advice, diagnosis, or treatment. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. AMD and the speaker do not recommend or endorse any specific course of treatment, products, procedures, opinions, or other information that may be mentioned. Reliance on any information provided by this content is solely at your own risk.