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The Let Down Effect: Why You Get Migraine Attacks on Weekends & Vacations
Episode 8
Wednesday, 7 January, 2026
Do you always seem to get a migraine attack on the weekend or vacation? In this episode of Spotlight on Migraine, host Molly O'Brien talks with neurologist Dr. Hope O'Brien about the let-down effect. This common but lesser-known migraine phenomenon can occur when the body shifts from high stress to relaxation. Dr. O'Brien discusses why so many people with migraine experience let-down headaches and what you can do about it. If you've ever wondered why a migraine attack hits right when you slow down, this episode has answers, validation, and guidance. Read the transcript at: https://www.migrainedisorders.org/podcast/s7ep8-the-let-down-effect *The contents of this video are intended for general informational purposes only and do not constitute professional medical advice, diagnosis, or treatment. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. AMD does not recommend or endorse any treatment, products, or procedures mentioned. Reliance on any information provided by this content is solely at your own risk.
