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LSHTM ViralAuthor: LSHTM
An award-winning podcast focusing on the science behind public and global health, and solutions to improve health and health equity worldwide. Brought to you from the London School of Hygiene & Tropical Medicine. Language: en Genres: Life Sciences, Science Contact email: Get it Feed URL: Get it iTunes ID: Get it Trailer: |
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Winter Flu Alert: H3N2, Early Spikes, and the Universal Vaccine Quest
Episode 6
Friday, 5 December, 2025
If your morning commute sounds coughier than usual, you aren't imagining things.Reports confirm that the UK flu season has kicked off weeks ahead of schedule. With COVID-19 and RSV also circulating, are we facing a "tripledemic"? And why does the flu virus shape-shift enough to require a new vaccine every single autumn?In this episode, host Karl Byrne sits down with Professor Punam Mangtani, a leading epidemiologist at the London School of Hygiene & Tropical Medicine (LSHTM), to decode the data behind this year's outbreak.They explain the difference between the H1N1 and H3N2 strains, why the UK looks to Australia for warning signs, and the biological "typo" that causes the virus to drift away from our immune system's memory. Plus, we look at how mRNA vaccine technology can help us tackle flu pandemics faster, and ask: Are we getting closer to a "universal" vaccine?In this episode, we cover:01:45 – The Early Surge: Why school data signals a difficult winter ahead.02:4 8 – The Australia Warning: What the Southern Hemisphere tells us about case numbers vs. severity.03:50 – H3N2 vs. H1N1: Decoding the alphabet soup of viral strains.05:13 – The Tripledemic: How Flu, RSV, and COVID-19 interact (and why you probably won't catch them all at once).07:10 – Antigenic Drift: The molecular reason why last year's vaccine won't protect you this year.08:35 – The Prediction Game: How the WHO selects vaccine strains months in advance.10:37 – 60% effectiveness?: How effective must a vaccine be in order to be thought of as good?12:55 – The Holy Grail: The latest research on Universal Flu Vaccines.14:23 – Prevention: Why surface cleaning works better for Flu than it did for COVID.Guest:Professor Punam Mangtani – Professor of Clinical Epidemiology at LSHTM and expert in respiratory viruses, vaccine effectiveness, and public health surveillance.Learn more:LSHTM Vaccine CentreExpert Comment: Why the UK is expecting a bad flu seasonCredits:Host: Karl ByrneProducer: Karl ByrneEditor: Karl ByrneFollow us on social media:Twitter: @LSHTMInstagram: @LSHTM#LSHTM #GlobalHealth #Flu #H3N2 #PublicHealth #Vaccines #Epidemiology #Tripledemic
