Altasciences

As an end-to-end CRO/CDMO, we have expert knowled

Author: The Altascientist

As an end-to-end CRO/CDMO, we have expert knowledge in all early stages of drug development, and were sharing that knowledge with you in The Altascientist: The Audiobook. Each issue is a deep dive into a specific area of early-phase drug development, providing insider tips, considerations, and case studies. Altasciences is a drug development solution company offering pharmaceutical and biotechnology companies a proven, flexible approach to preclinical and clinical pharmacology studies, including formulation, manufacturing, and analytical services.
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Issue 46 — Spray-Dried Dispersions
Friday, 10 October, 2025

In this issue, we examine spray-dried dispersions (SDDs) as an effective method to improve solubility and bioavailability of your active pharmaceutical ingredient (API) in early-phase drug development. We review the spray drying process, which converts a liquid into a dry powder, and how the resulting SDDs benefit from improved characteristics for further development. We also discuss the combination of spray drying with nanomilling for further bioavailability improvements and flexible downstream processing. Additionally, we explore the applicability of testing proof-of-concept, as well as creating material for first-in-human (FIH) clinical trials. Leveraging our in-house preclinical services, we also have the unique capability to test spray-dried material versus raw API in vivo, generating meaningful data to compare with in vitro test results.