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The Metabolic Classroom with Dr. Ben BikmanRaise Your Insulin IQ for Improved Metabolic Health Author: Insulin IQ
Welcome to The Metabolic Classroom, a nutrition and lifestyle podcast focused on metabolism, which is how our bodies use energy, and the truth behind why we get sick and fat. Every week, Dr. Ben Bikman shares valuable insights that you can apply in your own life and share with friends and loved ones. The Metabolic Classroom is brought to you by BenBikman.com and InsulinIQ.com. Hosted on Acast. See acast.com/privacy for more information. Language: en Genres: Health & Fitness, Life Sciences, Nutrition, Science Contact email: Get it Feed URL: Get it iTunes ID: Get it Trailer: |
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Ketones and Your Heart - How Ketones Protect the Cardiovascular System
Episode 127
Monday, 24 November, 2025
Listen Ad-Free: https://benbikman.comIn this Metabolic Classroom mini lecture, Dr. Bikman explores the powerful effects of ketones—particularly beta-hydroxybutyrate (BHB)—on the cardiovascular system. While ketones are typically thought of as a backup fuel, Ben explains how they are, in fact, an adaptive and efficient energy source that can support heart function in both healthy and failing states.Ben breaks down groundbreaking studies showing that ketones increase cardiac output, reduce vascular resistance, and improve heart function—especially in heart failure cases. He highlights the unique ability of BHB to reduce “afterload,” or the resistance the heart must pump against, effectively easing the heart’s workload. He also details ketones’ role in promoting vasodilation by acting on endothelial cells and smooth muscle, increasing nitric oxide and improving overall circulation.Beyond fuel metabolism, BHB also acts as a signaling molecule with epigenetic and anti-inflammatory effects. It can modulate gene expression by influencing histone acetylation and β-hydroxybutyrylation, leading to improved antioxidant defense and reduced inflammation via inhibition of the NLRP3 inflammasome—a key player in heart failure and atherosclerosis.Finally, he touches on the practical implications, suggesting both ketogenic diets and exogenous ketone supplements—particularly L-BHB—as viable strategies for enhancing cardiovascular resilience. This lecture positions ketones not just as fuel, but as potent metabolic signals capable of supporting and even restoring heart health.Show Notes/References:For complete show notes and references, we invite you to become an Insider subscriber or member. You’ll enjoy real-time, livestream Metabolic Classroom access which includes live Q&A with Ben after the lecture, unlimited access to Dr. Bikman’s Digital Mind, ad-free podcast episodes, show notes and references, and online, live Office Hours access with Ben. It also includes Ben’s Weekly Research Review Podcast. Learn more: https://www.benbikman.comIMPORTANT NOTE: The information presented is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Dr. Bikman is not a clinician—and, he is not your doctor. Always seek the advice of your own qualified health providers with questions you may have regarding medical conditions. Hosted on Acast. See acast.com/privacy for more information.
