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Precision EvidenceAuthor: Kim Kristiansen & JG Staal
At the Precision Evidence Podcast, we go beyond the abstract of medical papers to find medical research relevant and meaningful to patients and healthcare professionals and separate the news from the fake news in medicine. Finding, evaluating, and using clinical trials with relevant outcomes for patients and Evidence-Based Medicine is the focus of the podcast's analysis of medical papers, discussions, and interviews with stakeholders. Hosted by Dr. Kim Kristiansen, M.D., and JG Staal. Twitter: @PrecisionEBM email us at podcast@precision-evidence.com Language: en-us Genres: Health & Fitness, Life Sciences, Medicine, Science Contact email: Get it Feed URL: Get it iTunes ID: Get it |
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Clinical Trials and Surrogate Outcomes (13)
Episode 13
Tuesday, 27 July, 2021
Clinical Trials & Surrogate Outcomes Looking for clinical relevance means looking for a lot of details. A crucial part of that is looking at WHAT is compared with WHAT But what if a comparison is not clinically relevant - what do you do then? And how about studies using surrogate outcomes perhaps even approved by the FDA - they must be clinically relevant - but are they? In this episode, we talk about how to navigate this and find the best available research You don't want to miss this episode Get the Precision Evidence Newsletter https://bit.ly/3tLBx3Z LINKS: Assessment of Overall Survival, Quality of Life, and Safety Benefits Associated With New Cancer Medicines Supplemental content, JAMA Oncology (2017) https://jamanetwork.com/journals/jamaoncology/fullarticle/2594542 FDA Approved Surrogate Endpoints: https://www.fda.gov/drugs/development-resources/table-surrogate-endpoints-were-basis-drug-approval-or-licensure Virtual Reality Smartphone-Based Intervention for Smoking Cessation: Pilot Randomized Controlled Trial on Initial Clinical Efficacy and Adherence https://www.jmir.org/2020/7/e17571/ NOTES: Finding clinically relevance in what is compared with what in a clinical trial How can we know what a relevant comparison is? Different kinds of comparisons in clinical research The pro and cons of surrogate endpoints Examples of surrogate endpoints you should avoid Outcomes in oncology research FDA rules When is information from placebo trials relevant - and when isn't it relevant Research with no comparator, when can that be useful? GET THE ABSTRACT SCREENING TOOL It can be a challenge to screen papers for clinical relevance. As we go beyond the abstract in this podcast, we have created a screening tool to use when reading an abstract from a clinical research paper. Using that tool enables you to quickly screen an abstract from a medical journal for clinical relevance selecting only those you want to read. At the same time, you will know why you skipped the rest. Get it at our website https://www.precision-evidence.com Contact us at email: podcast@precision-evidence.com, Twitter @PrecisionEBM, You can learn more at our website, where you can also leave us a voice message. Website: www.precision-evidence.com Hosts: Dr. Kim Kristiansen, M.D: @KKristiansenMD & https://www.linkedin.com/in/kim-kristiansen JG Staal: @HealthyEvidence Music thanks to mixkit.co
