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VerifiedRxAuthor: Vizient Center for Pharmacy Practice Excellence
Delivering short doses of insight for hospitals frontline pharmacy professionals, the Vizient pharmacy team brings together experts to verify best practices for navigating todays pharmacy practice challenges and accelerating career growth. Its a prescription for success, delivered by the Vizient Center for Pharmacy Practice Excellence. Language: en Genres: Health & Fitness, Medicine, Science Contact email: Get it Feed URL: Get it iTunes ID: Get it |
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Alpha-gal Syndrome and Impact on Patient Safety
Episode 127
Tuesday, 28 April, 2026
Alpha-gal syndrome is an emerging and often underrecognized allergy triggered by a tick bite that can cause delayed reactions to red meat and mammalian-derived products. In this episode, host Stacy Lauderdale is joined by clinical experts Zack Stacy and Kyna Henrici to unpack the science behind alpha-gal, its implications in healthcare settings, and the operational challenges providers face in managing this complex condition. Guest Speakers: Zachary Stacy, Pharm.D., MS, FCCP, BCPS Clinical Pharmacy Specialist, Surgery BJC Health Kyna Henrici, RN Medical Evidence Director - Cardiovascular Vizient, Inc. Host: Stacy Lauderdale, Pharm.D., BCPS AVP, Evidence-Based Medicine Vizient, Inc. 00:05 – Introduction Podcast introduction and welcome to VerifiedRx 00:14 – What is alpha-gal syndrome Overview of alpha-gal syndrome Delayed allergic reactions after eating red meat Often linked to tick bites 00:48 – Meet the Guests Zack Stacy, clinical pharmacy specialist Kyna Henrici, medical evidence director 01:10 – Understanding the Allergy Alpha-gal is a carbohydrate in nonprimate mammals that can trigger an allergy in humans Key difference is delayed reaction timing Symptoms are not always easy to trace 01:32 – How It Develops Triggered by tick bites Immune system produces IgE antibodies Oral exposure to alpha-gal leads to delayed reactions IV exposure to alpha-gal can cause immediate reactions 02:17 – Prevalence and Diagnosis Challenges More common in Midwest and southern United States Likely underdiagnosed Often mistaken for general food allergies Allergy may fade over time 03:07 – Risks in Healthcare Settings Patient safety concerns beyond food Mammalian components in medications and devices Examples include heparin and surgical materials 03:44 – Hidden Medication Risks Inactive ingredients can be animal derived Examples include glycerin, lactose, amino acids, stearates Difficult to identify and track 04:42 – Lack of Transparency No centralized ingredient database Sourcing can change frequently Variability across manufacturers and batches 05:33 – Screening in Surgical Settings Medication review at NDC level Identification of active and inactive ingredients May require contacting manufacturers 06:45 – Timing Challenges Urgent procedures limit investigation time Manufacturer responses may take days Alternative medications often needed 07:14 – Identifying At Risk Patients Many patients are unaware they have alpha-gal syndrome Screening includes questions about dairy tolerance Three patient categories used for evaluation 08:32 – Using Dairy as a Screening Tool Dairy tolerance helps guide risk level Food exposure typically higher than medication exposure Determines need for deeper review 09:12 – Managing Emergencies Focus shifts from avoidance to risk mitigation Use of team communication and clear documentation Preparation for unavoidable exposure 10:03 – Prevention and Preparedness Stock alpha-gal safe medications when possible Prepare for allergic reactions with standard treatments 10:47 – Team Based Care Approach Collaboration across care teams is essential Premedication strategies may be used Close monitoring for reactions 11:11 – Gaps in Care Limited visibility into product ingredients Need for better labeling and transparency 11:33 – Need for Standardization Call for clearer guidance and clinician education Desire for centralized resource for medication ingredients 12:24 – Monitoring Challenges CDC tracking decreased after privatization of testing Cases likely still increasing 12:53 – Closing Remarks Links and Resources: Alpha-gal Syndrome | Alpha-gal Syndrome | CDC Subscribe Today! Apple Podcasts Spotify YouTube RSS Feed
