Neurology: Disease Deep Dive

Author: Practical Neurology

The field of neurology is vast and complex. This series provides thorough conversations with key expert physicians on neurologic conditions including the evolution of our understanding and treatment of these conditions.
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Language: en

Genres: Life Sciences, Science

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Detecting Multiple Sclerosis Earlier: PRLs and the Evolving McDonald Diagnostic Criteria
Monday, 15 December, 2025

This episode explores new evidence showing that paramagnetic rim lesions (PRLs) are highly prevalent early in multiple sclerosis (MS) and can differentiate MS from mimics with striking accuracy. Dr. Daniel Ontaneda, Cleveland Clinic Lerner College of Medicine, Cleveland, OH, and Dr. Pascal Sati, Cedars-Sinai Medical Center, Los Angeles, CA, discuss how PRLs, paired with optimized susceptibility-based MRI, are reshaping diagnostic confidence and informing the latest revisions to the McDonald criteria.