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The Lattice (Official 3DHEALS Podcast)Author: 3DHEALS
Welcome to the Lattice podcast, the official podcast for 3DHEALS. This is where you will find fun but in-depth conversations (by founder Jenny Chen) with technological game-changers, creative minds, entrepreneurs, rule-breakers, and more. The conversations focus on using 3D technologies, like 3D printing and bioprinting, AR/VR, and in silico simulation, to reinvent healthcare and life sciences. This podcast will include AMA (Ask Me Anything) sessions, interviews, select past virtual event recordings, and other direct engagements with our Tribe.While there is no rule for our podcast content, the only rule we follow is to provide our listeners with a maximized return on their attention and time investment.Follow us on Facebook, Twitter, and Instagram @3dheals, and check out the links in the show notes. 3DHEALS Links: https://linktr.ee/3dheals DisclaimerThe content of this podcast is for informational and educational purposes only and does not constitute medical, legal, or financial advice. The views and opinions expressed by the host and guests are their own and do not necessarily reflect those of their employers, affiliates, or any associated organizations.While we discuss emerging technologies in healthcare and 3D printing, listeners should consult qualified professionals before making decisions based on the information shared. The mention of specific companies, products, or technologies does not imply endorsement.This podcast may reference early-stage innovations and concepts that are not yet FDA-approved or commercially available. Always follow regulatory guidelines and ethical standards when applying new technologies in clinical or professional settings. Language: en-us Genres: Life Sciences, Science, Technology Contact email: Get it Feed URL: Get it iTunes ID: Get it |
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Episode#124| Live Event Recording: NAMs-From Theories to Validations
Saturday, 22 August, 2026
Speaker bio: https://3dheals.com/new-approach-methodologies-from-theory-to-validation/On demand video link: Coming soonYouTube: Coming soon Subscribe to future eventsWhat does it take for a biologically sophisticated model to become a tool that pharma, CROs, and regulators can actually trust?In this 3DHEALS panel, experts in human-relevant in vitro models, 3D bioprinting, organoids, microfluidics, and drug development explore the transition from promising New Approach Methodologies (NAMs) to decision-ready assays. The discussion moves beyond the simplistic question of whether NAMs can replace animal models and instead focuses on a more practical challenge: how can these systems generate reliable evidence that improves drug-development decisions earlier?Mike Clements examines the path from stem-cell-derived cardiac safety assays to regulatory-facing tools, including the importance of functional readouts, reproducibility, standardization, and clear context of use. Graham Craig brings a commercial perspective on why NAMs create value when they help teams advance, deprioritize, or stop programs before expensive downstream studies. Andrew Lee discusses fit-for-purpose 3D-bioprinted cardiac tissues designed to measure contractility, conduction, calcium dynamics, and arrhythmogenic behavior. Pranav Joshi explains how organoids can become assay-ready through engineering control, lifecycle quality control, standardized recovery, and transferable workflows. Alexandre Civiere shares practical skin-on-chip applications spanning permeation, wound healing, and tissue-aging models.The panel also addresses adoption bottlenecks: model complexity versus utility, physiologic relevance, cell density, operator variability, QC gates, automation, standardization, regulatory engagement, and the role of cross-sector consortia.Featuring:Dr. Mike Clements, Axion BioSystemsGraham Craig, Voxell BioAndrew Lee, FluidForm BioPranav Joshi, Bioprinting LaboratoriesAlexandre Civiere, Revivo BiosystemsModerated by Dr. Lowry Curley, Luna LifeSci00:01:20 - 3DHEALS Mission And Networking00:03:11 - Why Most Stem Cell Models Stall00:05:40 - Cardiac MEA Assays And Regulators00:10:32 - Standardization Roadmap From CIPA00:14:33 - The Commercial Case For NAMs00:19:20 - Fit For Purpose Beats More Complexity00:27:08 - 3D Bioprinted Cardiac Tissues In Practice00:35:12 - Arrhythmia Patterns And Disease Geometry00:39:30 - Organoids To Assay Ready Workflows00:45:57 - QC Gates Across The Organoid Lifecycle00:50:02 - Skin Chips Permeation And Wound Healing00:56:43 - Aging Models And Regulatory Reality00:59:29 - Panel What Changed In Five Years01:07:55 - Adoption Where It Moves Fast01:13:20 - Physiological Relevance Versus Reproducibility01:15:03 - Standardization Who Must Drive It01:21:30 - Operator Variability And Automation Fixes01:27:30 - Contamination And Process Traceability01:30:12 - Why Organ Chips Still Lag01:35:55 - AI That Helps Versus AI Theater01:41:50 - How Much Animal Testing Can Shift01:44:10 - Final Hopes And How To HelpSend us Fan MailSupport the showSubscribe to our premium version and support the show. Follow us: Twitter Instagram Linkedin 3DHEALS WebsiteFacebookFacebook GroupYoutube channelAbout Pitch3D
