Columbia University BioWorks

Author: Columbia University Systems Biology Initiative

Welcome to BioWorks - a podcast focused on life science business, entrepreneurship, policy, and investment. Listen in to hear conversations with a diverse array of guests making "bio work" in the real world! If you're interested in other ways in which biology is impacting the world, check out our sister podcast "Bio Bytes" (https://podcasters.spotify.com/pod/show/biobytes) for great discussions with prominent scientists working at the intersection of biology, engineering, medicine, computer science, and mathematics. For any inquiries, please contact ao2764@columbia.edu
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Language: en

Genres: Life Sciences, Science

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BioWorks 26: Building Organoids Models and Active Learning Algorithms with Arvind Thiagarajan
Thursday, 12 February, 2026

In which Arvind Thiagarajan, Co-founder and CTO of Tessel Biosciences, shares how he is combining organoid models with active learning algorithms to generate clinically-relevant data with greater experimental efficiency to ultimately develop novel therapeutics. He also discusses how his prior experiences at MIT, D.E Shaw, BenevolentAI, and Verily each shaped his career and worldview into the engineer and founder he is today. Hosted by Kevin Xu.Timestamps:(00:00) Intro(05:30) Takeaways from DESRES, BenevolentAI, and Verily(15:57) Speed, cost, and success rate trends in drug development(33:37) Core research workflow of Tessel Bio(44:09) Tesselogic and active learning(47:01) Coordinating wet-lab and dry-lab innovations(50:19) Advice for aspiring scientist-foundersLinks: Tessel Biosciences - https://tessel.bio/