 |
DMPK InsightsAuthor: Pharmaron
DMPK Insights is a by-monthly podcast by Pharmaron about the latest research and developments in DMPK science with a focus on three different areas:- Current Considerations: Breaking DMPK science with a focus on recent scientific publications, regulatory and other considerations - Influential Individuals: Key DMPK scientific influencers career path, research focus, future plans- Trending Technologies: Technological advances in DMPK science what does it do and why is it needed? Language: en-us Genres: Life Sciences, Science Contact email: Get it Feed URL: Get it iTunes ID: Get it |
Listen Now...
DMPK Insights #16: HR-LC/MS: A Key Consideration for Environmental Fate and Plant/Livestock Metabolism Studies
Episode 16
Monday, 8 December, 2025
For a captioned and video version or to access the transcript and ask a question for our experts about this podcast episode, please visit: https://www.pharmaron.com/knowledge-center/dmpk-insights-16-metabolism-studies/#cprtstatus=_cp_0!channel!AAIDoxPJjQQeIn this special episode of the Pharmaron DMPK Insights Podcast Series, our experts explore the critical role of metabolism studies in agrochemical research. The discussion focuses on metabolite identification and its importance in determining the environmental fate of agrochemicals and the metabolic pathways they undergo. By examining both the scientific foundations and practical applications, this episode highlights how metabolism studies support regulatory decision-making and environmental safety assessments.We will address the following points: Challenges within Environmental MetabolismRequirements for identification within regulatory studiesChallenges, e.g. application rate, volatility, matricesMethods for secondary confirmationTools to aid metabolite identificationHigh-Resolution LC-MS in PracticeHigh-resolution mass spectrometry (HRMS) instrumentationAnalytical challenges in agrochemical metabolism studiesUse of stable isotopesReal-world case studies in metabolism studiesOur Speakers:Mark Simmonds – Team Leader, Environmental Metabolism at PharmaronMark is the Team Leader for Environmental Metabolism at Pharmaron with more than 24 years’ experience working in the CRO industry, with the last ~4 years working in the Environmental Metabolism group at Pharmaron. He graduated with a degree in Chemistry from the University of Greenwich in 1995 studying for seven years whilst working for Rhône-Poulenc Agriculture – later becoming Aventis CropScience. In 2001, after the sale of the crop science division to Bayer, Battelle UK was formed, a CRO performing environmental fate, plant metabolism and residue studies and as an active study director, Mark took up the position of Researcher and remained in the environmental fate and plant metabolism arena for the next 20 years. In January 2021, Mark moved to Pharmaron as Environmental Metabolism Team Leader, overseeing the delivery of environmental fate, plant and livestock metabolism studies to our agrochemical clients and environmental risk assessments to our pharma clients.Dylan Williams – Team Leader, Metabolite Identification at PharmaronDylan is a Team Leader in Metabolite Identification at Pharmaron with more than 22 years’ experience working in the pharmaceutical CRO industry. He received his Ph.D. in Chemistry (specifically mass spectrometry) under Dr Rod Mason’s supervision at the University College of Wales, Swansea in 2002. Following his Ph.D, Dylan began his career with the regulated bioanalysis group at Biodynamics (now Pharmaron UK) before moving to the Pharmaron UK Metabolism department in 2004 where he joined the fledgling Metabolite Identification Team. In 2017, Dylan became the Team Leader for the Metabolite Identification Team and now leads a large, highly-experienced team, using accurate mass LC-MS to solve some of the most interesting scientific challenges for our clients.Stay tuned for more podcasts in our Pharmaron DMPK Insights Series!
