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The Genetics PodcastAuthor: Sano Genetics
Exploring all things genetics. Dr Patrick Short, University of Cambridge alumnus and CEO of Sano Genetics, analyses the science, interviews the experts, and discusses the latest findings and breakthroughs in genetic research. To find out more about Sano Genetics and its mission to accelerate the future of precision medicine visit: www.sanogenetics.com Language: en-us Genres: Natural Sciences, Science Contact email: Get it Feed URL: Get it iTunes ID: Get it |
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EP 188: Cracking the code of autism through genetics with Daniel Geschwind of UCLA
Episode 188
Thursday, 22 May, 2025
Summary: This week on The Genetics Podcast, Patrick is joined by Daniel Geschwind, Professor, Senior Associate Dean, and Associate Vice Chancellor of Precision Health at UCLA. They discuss the circuitous career path that led Daniel to building a biobank that provided the foundation for autism genetics, the complexity of the molecular and genetic aspects of autism, and how gene therapies could advance treatment. Show Notes: 0:00 Intro to The Genetics Podcast00:59 Welcome to Daniel and how he transitioned from being a chemistry teacher and consultant to an academic clinician05:51 How a year filming ski movies helped Daniel decide what he wanted to do after college07:29 How Daniel got started in autism research and established a biobank that built the foundation for autism genetics11:38 Our current understanding of autism on the molecular and genetic levels18:04 The spectrum nature of autism and how it correlates to molecular and genetic differences 25:13 The potential convergence of variants of autism on common pathways and corresponding therapeutics31:18 Evidence for the early developmental etiology of autism and the complexity of the genetic aspect35:56 The developmental window for gene therapies in autism and the need for concurrent training 38:41 Successes and barriers to data sharing and collaboration, and the importance of biobanks and functional mapping51:40 Developing computational tools for a network approach to transcriptomes55:28 Closing remarksPlease consider rating and reviewing us on your chosen podcast listening platform! https://drive.google.com/file/d/1Bp2_wVNSzntTs_zuoizU8bX1dvao4jfj/view?usp=share_link
