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The Genetics PodcastAuthor: Sano Genetics
Exploring all things genetics. Dr Patrick Short, University of Cambridge alumnus and CEO of Sano Genetics, analyses the science, interviews the experts, and discusses the latest findings and breakthroughs in genetic research. To find out more about Sano Genetics and its mission to accelerate the future of precision medicine visit: www.sanogenetics.com Language: en-us Genres: Natural Sciences, Science Contact email: Get it Feed URL: Get it iTunes ID: Get it |
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EP 222: From genetic risk to gene editing in heart failure with Travis Hinson of the Jackson Laboratory and University of Connecticut
Thursday, 15 January, 2026
This week on The Genetics Podcast, Patrick is joined by Dr. Travis Hinson, Professor and physician at the University of Connecticut and investigator at the Jackson Laboratory. They discuss how genetics is reshaping the understanding of heart failure, why sarcomere biology has become a central target for new gene-based therapies, and how advances in genome editing and preventive genetics could redefine cardiovascular care.Show Notes: 0:00 Intro to The Genetics Podcast01:00 Welcome to Travis01:44 Overview of gene editing for inherited cardiovascular disease05:01 Delivery methods and viral capsid engineering to target heart tissue07:29 Role of the titin gene in dilated cardiomyopathy and treatment opportunities10:32 Genetic variants in titin and differences in phenotype13:51 Promising therapeutic approaches for targeting titin 16:21 Possibility of using a mini titin gene for replacement17:31 Sarcomere proteins and their role in cardiomyopathy20:28 Limits of current understanding in heart failure, including cardiac regeneration and congenital heart disease24:50 Predicting drug-induced cardiotoxicity using stem cell models, animal studies, and digital twins30:02 How Travis balances clinical genetics at the University of Connecticut with translational research at the Jackson Laboratory (JAX)32:03 Where genetic testing is used in cardiology today and what’s limiting broader access35:19 Understanding polygenic risk and unexplained heritability in cardiovascular disease37:07 Managing inherited cardiomyopathy risk in families after a pathogenic variant is identified40:36 Genetic testing as a prevention strategy and the public health case for earlier intervention43:03 Balancing early genetic screening with penetrance, uncertainty, and patient anxiety45:51 Closing remarksFind out more:Review on cardiovascular gene editing approaches Please consider rating and reviewing us on your chosen podcast listening platform!
