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PsyDacticAuthor: T. Ryan O'Leary
A resource for psychiatrists and other medical or behavioral health professionals interested in exploring the neuroscientific basis of psychiatric disorders, psychopharmacology, neuromodulation, and other psychiatric interventions, as well as discussions of pseudoscience, Bayesian reasoning, ethics, the history of psychiatry, and human psychology in general.This podcast is not medical advice. It strives to be science communication. Dr. O'Leary is a skeptical thinker who often questions what we think we know. He hopes to open more conversations about what we don't know we don't know.Find transcripts with show-notes and references on each episodes dedicated page at psydactic.buzzsprout.com.You can leave feedback at https://www.psydactic.com.The visual companions, when available, can be found at https://youtube.com/@PsyDactic. Language: en-us Genres: Health & Fitness, Mental Health, Science Contact email: Get it Feed URL: Get it iTunes ID: Get it Trailer: |
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Clozapine - Beyond the Basics
Episode 76
Thursday, 4 September, 2025
Dr. O'Leary explores the history of clozapine, highlighting its initial revolutionary impact as the first atypical antipsychotic, followed by a ban on its use, followed by its re-emergences as a strictly monitored medication, and then culminating in new recommendations that greatly encourage its use. The discussion details the severe side effects that led to its initial discontinuation, and then emphasizes other critical but often overlooked adverse effects, such as metabolic syndrome, sialorrhea, and especially severe gastrointestinal hypomotility, which can be life-threatening. Please leave feedback at https://www.psydactic.com or send any comments to feedback@psydactic.com.References and readings (when available) are posted at the end of each episode transcript, located at psydactic.buzzsprout.com. All opinions expressed in this podcast are exclusively those of the person speaking and should not be confused with the opinions of anyone else. We reserve the right to be wrong. Nothing in this podcast should be treated as individual medical advice.
