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Beyond the AbstractScience and research for everyone Author: Beyond the Abstract
Hey science nerds! Welcome to Beyond the Abstract, a science podcast dedicated to discussion of the coolest cutting edge, basic science research papers in a way that just about anyone can understand. We're your hosts, Derek, Dan, and Ellen, three MD/PhD students coming from the University of Pennsylvania and Harvard Medical School who are passionate about science communication and bridging the gap between science and medicine. In each episode, well dive into a paper and talk about the experiments these scientists did, what it means for the future of research, and even potential impacts on human health and medicine. We've invited experts in these fields to help us understand and dissect these complicated but impactful papers. We can't wait to share all this cool science with you. Disclaimer: This podcast is for informational purposes only and NOT intended as medical advice. The views and opinions expressed are those of the hosts and guests and do not reflect the University of Pennsylvania. Business contact: beyondabstractpod@gmail.com Language: en Genres: Education, Life Sciences, Science Contact email: Get it Feed URL: Get it iTunes ID: Get it |
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Plaque Hacks: When it Comes to Statins, Consistency is Key
Episode 42
Monday, 27 January, 2025
Cardiovascular disease is the leading cause of global mortality. Among the many risk factors for cardiovascular disease, it's long been known that high cholesterol increases the risk for heart attacks and stroke. In today's episode of Beyond the Abstract, Derek and Dan discuss two new papers that challenge commonly held beliefs about the way in which cholesterol increases the risk for cardiovascular disease. They finish by talking about a new type of genetic medicine to lower cholesterol and reduce the risk for cardiovascular disease.Papers discussedAlternating high-fat diet enhances atherosclerosis by neutrophil reprogramming, Lavillegrand et al 2024 Naturehttps://www.nature.com/articles/s41586-024-07693-6Early intermittent hyperlipidaemia alters tissue macrophages to fuel atherosclerosis, Takaoka et al 2024 Naturehttps://www.nature.com/articles/s41586-024-07993-xZodasiran, an RNAi Therapeutic Targeting ANGPTL3, for Mixed Hyperlipidemia, Rosenson et al 2024 NEJMhttp://nejm.org/doi/full/10.1056/NEJMoa2404147Plozasiran, an RNA Interference Agent Targeting APOC3, for Mixed Hyperlipidemia, Ballantyne et al 2024 NEJMhttps://www.nejm.org/doi/full/10.1056/NEJMoa2404143
