American Journal of Psychiatry Audio

Author: American Journal of Psychiatry

Each episode of AJP Audio brings you an in-depth look at one of the articles featured in that months issue of The American Journal of Psychiatry, the official journal of the American Psychiatric Association. Wide-ranging interviews with article authors cover the background, rationale, main findings, and future implications of the research. This podcast is subject to the Terms of Use at ww.psychiatry.org. The views and opinions expressed in this podcast are those of the individual speakers only and do not necessarily represent the views of the American Psychiatric Association, its officers, trustees, or members. The content of this podcast is provided for general informational purposes only and is not intended as, and shall not be understood or construed as, medical or any other type of professional advice nor does it represent any statement of the standard of care. We strongly recommend that any listener follow the advice of physicians directly involved in their care and contact their local emergency response number for any medical emergency. The information within this podcast is provided as-is and is not guaranteed to be correct, complete, or accurate.
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March 2025: The Impact of Xanomeline and Trospium Chloride on Cognitive Impairment in Acute Schizophrenia: Replication in Pooled Data From Two Phase 3 Trials
Saturday, 1 March, 2025

Dr. William Horan (Bristol Myers Squibb) joins AJP Audio to discuss a newly approved, novel treatment for schizophrenia spectrum disorder, which has potential impacts for cognition in patients. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin puts the rest of the March issue into context. 00:45 Horan interview 03:15 Novel mechanism of action in the treatment of schizophrenia 05:39 Side effect profiles 07:20 Clinical impacts 08:31 The need for further investigation 09:58 Limitations 11:05 Further research 13:08 Kalin interview 13:21 Horan et al. 17:34 Levenstein et al. 19:00 Fountoulakis et al. 20:57 Couture et al. 23:18 Stern et al. 27:35 McGirr et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org