Alexander Disease Research Update

Author: Albee Messing

Monthly discussion of recent publications from the research literature on Alexander Disease, hosted by Albee Messing from the University of Wisconsin-Madison.
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Language: en-us

Genres: Health & Fitness, Medicine

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Alexander Disease Research Update – Episode #32: 1) GFAP variants and oxidative stress, and 2) GFAP variants and lysosomes
Friday, 15 May, 2026

Send us Fan MailAlbee Messing, Dolores Pérez-Sala, and Natasha Snider discuss the following recent publications: Alexander disease mutations differentially sensitize glial fibrillary acidic protein (GFAP) to posttranslational modifications and network disruption by oxidants. Redox Biology 92:104103 (2026) Lysosomal function, resistance to oxidative stress and repair are compromised by expression of the Alexander disease GFAP R239C mutant. Free Radical Biology & Medicine (in press)Send your questions and feedback to: amessing@wisc.eduHelp support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center: https://alexander-disease.waisman.wisc.edu/donate/ Podcasts are supported by Daniel's Fight (https://www.danielsfight.com)