EMplify by EB Medicine

Author: EB Medicine

Take a deeper dive into our peer-reviewed emergency medicine content with the EMplify podcast. Join hosts Sam Ashoo, MD and T.R. Eckler, MD for educational, conversational reviews of current evidence guaranteed to help you make your best clinical decisions. Each high-yield episode gives you practical, time-tested guidance from practicing emergency medicine clinicians and subject-matter experts. Listen and learn!
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Acetaminophen and Salicylate Toxicity
Wednesday, 30 September, 2026

In this episode, Sam Ashoo, MD and Dr. T.R. Eckler, MD discuss the September 2026 Emergency Medicine Practice article, Emergency Department Diagnosis and Management of Acetaminophen or Salicylate Toxicity1:13 — Welcome and topic introduction3:50 — Key rules: check levels, call Poison Control5:13 — Acetaminophen pathophysiology8:16 — Salicylate pathophysiology10:51 — Coingestions11:11 — Differential diagnosis12:19 — History & pre-hospital care15:28 — Product confusion17:08 — Toxic dose thresholds18:26 — Physical exam & vital signs20:16 — Acetaminophen toxicity stages (1-4)22:35 — Salicylate exam findings23:43 — Lab workup & testing24:45 — Acetaminophen nomogram & levels30:39 — Activated charcoal — when to give it34:11 — NAC therapy — dosing & timing37:22 — Hemodialysis for acetaminophen38:40 — King's College Criteria41:00 — Salicylate treatment44:42 — Potassium management during alkalinization47:28 — Hemodialysis for salicylate48:05 — Intubation50:00 — Pregnancy considerations51:20 — Pediatric considerations52:06 — Emerging: fomepizole as adjunct therapy52:45 — Summary & wrap-upSubscribers, take the CME test here.Emergency Medicine Residents, get your free subscription by writing resident@ebmedicine.net