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The mTOR You KnowAuthor: The mTOR You Know
The mTOR you know is a solid organ transplant podcast produced by the ACCP Transplant PRN. Please follow @themTORyouknow on X! Language: en Genres: Health & Fitness, Medicine Contact email: Get it Feed URL: Get it iTunes ID: Get it |
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Decoding donor-derived cell-free DNA (dd-cfDNA)
Wednesday, 30 September, 2026
What does an elevated dd-cfDNA actually mean—and what doesn’t it mean? In this episode of mTOR You Know, Lauren Schumacher and Kimberly Leale sit down with Dr. Adele Shields and Dr. James Fleming to get into the practical side of using donor-derived cell-free DNA in solid organ transplantation. We talk through how to interpret results, when dd-cfDNA is most useful, common pitfalls and things we might be tempted to over-interpret, how it fits alongside other tools for assessing allograft injury, and what we still need to learn. Plus, we dig into where pharmacists fit into all of this and where the field might be headed next.Currently approved dd-cfDNA tests:CareDx (AlloSure) :Kidney + SPK: AlloSure KidneyHeart: AlloSure HeartLung: AlloSure LungNatera (Prospera):Kidney: Prospera KidneyHeart: Prospera Heart with DQS – dd-cfDNA combined with Donor Quantity Score (DQS) Lung: Prospera LungLiver: Prospera LiverTransplant Genomics/EurofinsKidney: TRACLiver: OmniGraf – dd-cfDNA combined with gene expressionNot to be confused with rejection gene expression assays:Kidney: TruGraf – Transplant GenomicsLiver: OmniGraf – Transplant GemonicsHeart: AlloMap - CareDx
