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iCritical Care: Virtual Critical Care Rounds PodcastAuthor: Society of Critical Care Medicine (SCCM)
The Society of Critical Care Medicine (SCCM) Podcast features in-depth interviews with leaders in critical care. Experts discuss hot topics in intensive care with perspectives from all members of the critical care team. Guests include authors from SCCMs peer-reviewed journals, Critical Care Medicine, Pediatric Critical Care Medicine, and Critical Care Explorations, as well as thought leaders within the field. This is a new and updated channel, formerly known as the iCritical Care Podcast All Audio Channel. Language: en-us Genres: Health & Fitness, Medicine Contact email: Get it Feed URL: Get it iTunes ID: Get it |
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SCCMPod-558: The Future of Xenotransplantation
Episode 557
Wednesday, 26 November, 2025
In this episode of the Society of Critical Care Medicine (SCCM) Podcast, host Diane C. McLaughlin, DNP, AGACNP-BC, CCRN, FCCM, speaks with Muhammad Mansoor Mohiuddin, MD, MBBS, DSc (Hon), FAST, director of the Cardiac Xenotransplantation Program at the University of Maryland School of Medicine, about his Thought Leader presentation at the 2025 Critical Care Congress, The Remarkable Potential of Xenotransplantation, and his groundbreaking work on that subject. Dr. Mohiuddin discusses the need to address the global shortage of donated organs and the use of genetically modified pig organs as a viable solution. He explains the science behind xenotransplantation, including the use of CRISPR-Cas9 gene editing technology to delete immunogenic pig genes and insert human-compatible genes. The conversation explores the unique immunologic challenges of xenotransplantation, particularly antibody-mediated rejection and the need for tailored immunosuppression protocols. Ethical considerations include religious perspectives and public opinion. Dr. Mohiuddin emphasizes the importance of continued research funding and collaboration with industry partners to advance clinical trials and refine genetic modifications. Listeners will gain insight into how decades of research are transforming xenotransplantation and its potential to extend life and reshape the future of organ transplantation.
