Double-stranded Author: Mike Kaz Exploring the fascinating world of genetics and its impact on human health! We break down complex science topics like DNA, genome wide association studies, CRISPR gene editing, and epigenetics into accessible conversations. Join us for weekly episodes covering cutting-edge biology research and how your genome shapes your health. Subscribe for the latest genetic discoveries explained simply! Be a guest on this podcast Language: en-us Genres: Science Contact email: Get it Feed URL: Get it iTunes ID: Get it Get all podcast data

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The Killer Gene That FOUGHT BACK
Monday, 29 September, 2025

In this deep dive, we break down the journey of the PIM Kinase target. We explore the complex PIM1 molecular mechanism, examine why first-generation pan-PIM inhibitors like AZD-1208 faced safety issues and a lack of monotherapy efficacy, and reveal the final clinical verdict of the Terminated and Completed Phase 1 studies.📖 Video Chapters:0:00 - Intro1:05 - Biobanks Associations for PIM122:18 - PIM1 Gene39:00 - PIM1 Protein52:52 - PIM1 Known Drugs and Clinical Trials

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