Longevity Roadmap

Author: Buck Joffrey

Dr. Buck Joffrey sits down with leading scientists in the field of longevity to explore cutting-edge research, emerging therapies, and what it really takes to live longerhealthier.
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Language: en

Genres: Alternative Health, Health & Fitness

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169: Protein Folding Errors Contribute to Aging and Disease
Monday, 5 January, 2026

In this episode, we are joined by Dr. Judith Frydman to explore proteostasis: the tightly regulated systems that ensure proteins are correctly folded, maintained, and cleared before they become toxic. As these systems degrade with age, misfolded proteins accumulate, cellular signaling falters, and vulnerability to neurodegeneration increases. The discussion centers on why protein folding begins during translation, how molecular chaperones like TRIC preserve cellular integrity, and why aging creates a self-reinforcing cycle of proteostatic failure. We also examine upstream mechanisms—and what restoring proteostasis could mean for future longevity interventions, healthspan preservation, and disease prevention. Watch the full episode to understand why protein folding may be one of the most underappreciated levers in aging biology.