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Dr. GPCR PodcastAuthor: Dr. Yamina Berchiche
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The Beta-2 Agonist That Doesn't Stop Working — Tore Bengtsson
Episode 185
Wednesday, 6 May, 2026
Every beta-2 agonist ever tested for muscle growth hits the same wall: desensitization. Dr. Tore Bengtsson built one that doesn't.A professor at Stockholm University and founder of Atrogi, Dr. Bengtsson has spent 25 years studying how beta-adrenergic receptors regulate metabolism, muscle, and brown fat. His lab developed 1,500+ compounds that activate beta-2 through distinct signaling pathways, and one is now heading into Phase 2 clinical trials. He shares how a "failed" experiment cracked the problem, why incretins only address half of metabolic disease problems, and what muscle loss after 50 means for drug discovery strategy.Key takeaways:Classical beta-2 agonists fail because desensitization shuts down the responseSelectively activating specific signaling pathways from one receptor can produce entirely different outcomesIncretins reduce energy intake — but the energy expenditure side remains wide openThe correlation between muscle mass and longevity is one of the most underserved areas in metabolic medicine🔗 Dr. GPCR Ecosystem: https://www.ecosystem.drgpcr.com/🎓 Membership & Pricing: https://www.ecosystem.drgpcr.com/university-pricing📰 Weekly News: https://www.ecosystem.drgpcr.com/gpcr-weekly-news
