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From Concept to Medicine - A Comprehensive Drug Development JourneyAuthor: Jim Mitchell
Welcome to a Complete Drug Development Journey!Have you ever wondered how groundbreaking medicines go from a scientists vision to life-saving treatments in hospitals and pharmacies worldwide? The journey of drug development is an intricate, high-stakes adventurefilled with scientific breakthroughs, regulatory twists, and the relentless pursuit of innovation.In this podcast, we take you behind the scenes of pharmaceutical research and development, unraveling the complex and fascinating process that transforms a promising compound into a fully approved, market-ready medicine. Each episode is a deep dive into the critical stages of drug development, including: Drug Discovery: Where innovation beginsexploring cutting-edge research, target identification, and the quest for the next medical breakthrough. Preclinical Testing: Investigating safety, efficacy, and mechanisms of action before a drug ever reaches human trials. Clinical Trials: The rigorous, high-stakes world of human testingwhat works, what fails, and what it takes to get to the finish line. Regulatory Approval: Understanding the intricate web of global regulatory agencies, FDA submissions, and the make-or-break moments for new drugs. Manufacturing & Scale-Up: From lab to large-scale productionhow pharmaceutical companies tackle formulation, stability, and distribution challenges. Market Access & Commercialization: The economics of drug developmentpricing, market dynamics, and the delicate balance between innovation and accessibility.Whether you're a scientist, industry professional, investor, or simply fascinated by the inner workings of the pharmaceutical world, this podcast brings you expert insights, real-world case studies, and in-depth discussions on the past, present, and future of drug development.Join us as we demystify the science, strategy, and business behind the medicines that change lives. Subscribe now and be part of the journey!Access the Notion Template for cGXP Training Modules here: h Language: en Genres: Chemistry, Courses, Education, Science Contact email: Get it Feed URL: Get it iTunes ID: Get it |
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21 Atorvastatin (S24E21)
Episode 21
Sunday, 24 August, 2025
Nearly 45% of all deaths from non-communicable diseases worldwide are caused by cardiovascular disease—a staggering reality that frames the story of atorvastatin, better known as Lipitor. In this episode of From Concept to Medicine’s Periodic Table of Medicine, we trace the full journey of one of the world’s most influential drugs.From the centuries-long unraveling of cholesterol’s chemistry, through the serendipitous discovery of early statins in the 1970s, to Pfizer’s launch of atorvastatin in 1997, this episode dives deep into the science, medicine, and controversy behind a blockbuster. We explore how atorvastatin works to lower LDL cholesterol, its clinical uses from common hyperlipidemia to genetic conditions, and its role in reducing heart attack and stroke risk. Along the way, we unpack the intricacies of pharmacology, drug interactions, and safety considerations—while also pulling back the curtain on its complex manufacturing, regulatory battles, and high-stakes patent wars.But atorvastatin’s impact goes beyond the lab and the clinic. We look at its cultural imprint, from billion-dollar sales and household recognition to heated debates over marketing ethics and the shift to affordable generics. What emerges is a sweeping view of how one molecule reshaped global health, transformed an industry, and sparked questions about access, innovation, and trust in medicine.
