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Last Week in MedicineAuthor: Stephen Jenkins, MD, Austin Rupp, MD
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2026 ACC/AHA Guidelines for Acute Pulmonary Embolism
Episode 65
Tuesday, 10 March, 2026
The ACC/AHA published new guidelines for managing acute PE on February 19, 2026. Today I'm joined by Dr. Scott Woller, MD, MACP, FCCP, who was co-chair of the American College of Chest Physicians Clinical Practice Guideline for antithrombotic therapy for venous thromboembolism, last updated in 2021. He also served as co-chair for the peer review committee for these new guidelines, and has lots of great insights into how to use them in clinical practice and research. 2026 ACC/AHA Guidelines for Diagnosis and Managing Acute PESome highlights from the guidelines:New categories of PE: A: asymptomaticB: symptomatic, low riskC: symptomatic, high riskD: incipient shockE: cardiogenic shockPE response teams (PERTs) are ascendantUse enoxaparin instead of heparin drip!Advanced therapies for category D and EHalf dose DOACs for extended treatmentShared decision making for clots provoked by minor risk factorsPatients with persistent symptoms need evaluation for CTEPDMusic from Uppbeat (free for Creators!): https://uppbeat.io/t/soundroll/dope License code: NP8HLP5WKGKXFW2R













